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For example, the tooling area might try to get higher build counts for certain parts to create a window for work to be done on a die or xture 6528 Product, Process, Manufacturing, and Industrial Engineering There are three possible engineering groups that the production control department might have functional interconnections to The actual linkages will depend on physical location corporate structures and company processes For example, product engineering might be in a different country or supplied by the customer, and industrial engineering merges the product and process information and provides a single contact point In many cases, engineering owns the product and process information; data management, integrity, and communication are especially crucial when new products are produced, when engineering changes are introduced to the product or process or material, and when products are phased out.

Figure 9.30. Modelling three-dimensional protein structures from sequence. Two general approaches are possible. (a) Ab initio modelling is based on calculating a low energy structure based on interactions within the protein and between the protein and solvent. (b) Homology modelling calculates a structure based on a pre-existing structure in the PDB for a protein (template) showing sequence similarity to the target protein. SCRs are found by sequence alignment and coordinates of these are obtained from the PDB. Gap regions are modelled by searching the PDB for loops of similar length, geometry and sequence. The coordinates for these are similarly added to the model. The sequence of loops is converted to that of the target protein and a nal structure calculated by energy minimization.

In these various cases, engineering needs to make sure that (a) product information is in the information systems, (b) the actual information is available on the shop oor in time, and (c) tools and machines have been tested These are the obvious duties and responsibilities of the various engineering organizations There are also other special aspects of the engineering to production control interface There are the estimates which are used in planning for times, ef ciencies, waste, and so on There is the necessary communication about how these might change based on context and what is planned The timing of changes and introductions is also important so that the various manufacturing resources are used wisely For example, while it is common sense to introduce changes on Tuesday, Wednesday, and Thursday day shift and avoid evenings, weekends, and scal pressure points (eg.

Failure to maintain appropriate insurance cover over the period of the contract The capacity to continue providing the required service in the event of a major or extreme risk occurrence

, last week of the scal month), we have observed many cases where the operational implications of changes is not consciously considered The planner and scheduler might be able to in uence the change and timing of change, or even request or suggest a change, but the least they can do is to maintain close communication with the engineering groups By having timely intelligence about what might happen in the future, perceived and anticipated risks can be minimized or avoided 6529 Information Technology The scheduler can either have a very intense relationship with the Information Technology (IT) group or have hardly a relationship at all Usually, the scheduler uses some kind of transaction processing system to retrieve order data and possibly to release schedules It is hard to think of a company.

Cmr(w)

It s really hard to compare one LAN to another. There really isn t anything typical about any LAN. There are similarities in both design and functionality, but each LAN is unique. This LAN is your LAN, if you will. The concerns

Analyses of this type showed a fragmentation of the A. pleuropneumoniae genome into 6 12 fragments of molecular mass 11 1217 kb. Summing the sizes of all fragments for each serotype gave a total genome size of 22 283 to 2409 kb for this bacterium. Moreover, since signi cant polymorphism was evident in the digestion patterns of 12 of the 13 serotypes (see above). It was found possible to compare the degree of genetic relatedness between the serotypes using pulsed eld gel electrophoresis by analysing digestion patterns obtained with Apa I. This is summarized in the above dendogram comparing percentage similarity of digestion patterns with Apa I for each serotype. This analysis shows, for example, that serotypes 1, 9 and 11 are closely-related to each other while distantly related to serotype 4; This type of study gives useful information on genome size and the degree of relatedness between different strains of pathogenic bacteria. It is particularly appropriate in studying the geographical spread of such organisms and for monitoring the appearance and likely origins of new serotypes. Images reproduced from Chevallier et al., (1998) Chromosome sizes and phylogenetic relationships between serotypes of Actinobacillus pleuropneumoniae. FEMS Microbiol. Letts. 160, 209 16, by permission of the Federation of European Microbiological Societies.

Introduction System description Reference documents Validation activities, testing, acceptance criteria, and results Summary of deviations, problems, and mitigations